Dishevelled and Wnt signaling: is the nucleus the final frontier?
نویسندگان
چکیده
The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.
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BACKGROUND Dishevelled (Dsh) is a key component of multiple signaling pathways that are initiated by Wnt secreted ligands and Frizzled receptors during embryonic development. Although Dsh has been detected in a number of cellular compartments, the importance of its subcellular distribution for signaling remains to be determined. RESULTS We report that Dsh protein accumulates in cell nuclei wh...
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ورودعنوان ژورنال:
- Journal of Biology
دوره 4 شماره
صفحات -
تاریخ انتشار 2005